Durvalumab (anti-PD-L1)
CAS No. : 1428935-60-7
(Synonyms: MEDI 4736 (anti-PD-L1))
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $670 | In-stock |
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| Cat. No. : | HY-P9919A |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Durvalumab (anti-PD-L1)(MEDI 4736) is a human anti-PD-L1 protein monoclonal antibody. Durvalumab (anti-PD-L1) completely blocks PD-L1 binding to PD-1 and CD80, IC 50 are 0.1 and 0.04 nM respectively, has anti-tumor activity[1][2]. IC50 & Target:IC50: 0.1 nM (PD-L1/PD-1), 0.04 nM (PD-L1/CD80)[2] In Vitro:Durvalumab (0.02-20 μg/mL, 3 days) overcomes the inhibitory effect of PD-L1 on T cell activation[1]. In Vivo:Durvalumab (0.1-5 mg/kg, intraperitoneal injection, twice a week, three weeks) suppresses human tumor growth in mouse models through T cell inhibition[1].
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