Ilomastat
CAS No. : 142880-36-2
(Synonyms: GM6001; Galardin)
| Size | Price | Stock |
|---|---|---|
| 5mg | $119 | In-stock |
| 10mg | $198 | In-stock |
| 25mg | $370 | In-stock |
| 50mg | $594 | In-stock |
| 100mg | $900 | In-stock |
| 200mg | $1395 | In-stock |
| 500mg | $2903 | In-stock |
| 1g | $4500 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-15768 |
| M.Wt: | 388.46 |
| Formula: | C20H28N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 47 mg/mL |
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1). In Vitro: Ilomastat (GM6001) inhibits human skin fibroblast collagenase, thermolysin and elastase with Kis?of 0.4 nM, 20 nM, 20 nM, resepctively[1].?Ilomastat (0.1-10 nM) inhibits gelatinase A and gelatinase B produced by T-cells. Ilomastat inhibits T-cell homing[4]. In Vivo: Ilomastat (GM6001) (400 μg/mL) inhibits corneal ulceration after severe alkali injury in animals[2]. Ilomastat (GM6001) significantly suppresses intimal hyperplasia and intimalcollagen content. Ilomastat increases lumen area in stented arteries, shows no activity on proliferation rates in rabbit model after stenting[3].
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