U-73343
CAS No. : 142878-12-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $35 | In-stock |
| 5mg | $75 | In-stock |
| 10mg | $125 | In-stock |
| 50mg | $400 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-108630 |
| M.Wt: | 466.66 |
| Formula: | C29H42N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C) |
U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 µM for PLC[1][2]. In Vitro: U73343, which potently inhibits acid secretion, shows no inhibitory effect on either K+-pNPPase or H+,K+-ATPase activity. U73343 dose-dependently inhibits, histamine (Hist)-, carbachol (CCh)-, and dbcAMPstimulated aminopyrine accumulation in gastric glands[1].
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