VU0424465
CAS No. : 1428630-85-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $240 | In-stock |
| 10mg | $390 | In-stock |
| 25mg | $780 | In-stock |
| 50mg | $1250 | In-stock |
| 100mg | $2000 | In-stock |
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| Cat. No. : | HY-114978 |
| M.Wt: | 326.36 |
| Formula: | C19H19FN2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu5 mediated iCa2+ mobilization. VU0424465 exhibits high affinity at MPEP allosteric binding site, with a Ki value of 11.8 nM. VU0424465 is also a agonist for pERK1/2 in cortical neurons[1][2].
In Vitro: VU0424465 exhibits robust agonist activity and induces calcium mobilization in the absence of glutamate (EC50 = 171 ± 15 nM, maximum efficacy 65% compared to glutamate)[2].
VU0424465 potentiates glutamate-induced calcium mobilization, with EC50 of 1.5 ± 0.8 nM[2].
VU0424465 shows significant bias away from iCa2+ mobilization and toward IP1 accumulation (110-fold) and ERK1/2 phosphorylation (9-fold) in HEK293A-mGlu5-low cells[1].
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