Herboxidiene
CAS No. : 142861-00-5
(Synonyms: GEX1A)
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| Cat. No. : | HY-19828 |
| M.Wt: | 438.60 |
| Formula: | C25H42O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 4 mg/mL (ultrasonic;warming) |
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome[1][2].
In Vitro: Herboxidiene (24 hours) induces both G1 and G2/M arrest in a human normal fibroblast cell line, WI-38, with an IC50 of 7.6 nM[3].
Herboxidiene exhibits cytotoxicity against A431, A549, and DLD-1 cells with IC50s of 3.7, 21, 51 nM, respectively[3].
In Vivo: Herboxidiene (GEX1A) (1 mg/kg; i.p.; once) shows significant antitumor activity[3].
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