GDC-0339
CAS No. : 1428569-85-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $500 | In-stock |
| 10mg | $800 | In-stock |
| 50mg | $2600 | In-stock |
| 100mg | $4500 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16976 |
| M.Wt: | 465.50 |
| Formula: | C20H22F3N7OS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 52 mg/mL |
GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma[1][2].
IC50 & Target:Ki: 0.03 nM (Pim1), 0.1 nM (Pim2), 0.02 nM (Pim3)[2]
In Vitro: GDC-0339 is cytostatic, with an IC50 of 0.1 μM for MM.1S cells[2].
GDC-0339 treatment reveals a constellation of Pim downstream signaling events consistent with inhibition of Pim kinases[2].
In Vivo: GDC-0339 (1-300 mg/kg; p.o; daily; for 21 days) is efficacious in RPMI8226 and MM.1S human multiple myeloma xenograft mouse models[2].
GDC-0339 has a half-life of t1/2=0.9 h[2].
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