V-11-0711
CAS No. : 1428339-47-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $260 | In-stock |
| 5mg | $875 | Get quote |
| 10mg | $1380 | Get quote |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-120337 |
| M.Wt: | 421.57 |
| Formula: | C27H35NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
V-11-0711 is a potent and selective Chk-α (IC50 = 20 nM) inhibitor. V-11-0711 can significantly reduce PCho levels. V-11-0711 causes a reversible growth arrest. V-11-0711 induces apoptosis at high concentrations. V-11-0711 can be used for the study of cervical cancer and triple-negative breast cancer[1][2].
IC50 & Target:IC50: 20 nM (ChoKα)[1]
In Vitro:V-11-0711 (0.1-10 μM, 48 h) reduces PC and GPC levels in MDA-MB-231 cells and SUM149 cells[2].
V-11-0711 (0.1-10 μM, 48 h) does not reduce Chk-α protein levels in SUM149 cells at low doses, but reduces Chk-α protein levels by approximately 50% at high doses[2].
V-11-0711 (0.1-10 μM, 48 h) significantly reduces the level of PtdCho in SUM149 cells, and increases fatty acid levels at 10 μM[2].
V-11-0711 (0.1-10 μM, 48 h) increases the number of lipid droplets in SUM149 cells by approximately 1.8 times at 10 μM[2].
V-11-0711 (0.1-10 μM, 48 h) induces apoptosis in SUM149 cells at 10 μM[2].
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