JNJ-42253432
CAS No. : 1428327-35-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $230 | In-stock |
| 5mg | $560 | In-stock |
| 10mg | $820 | In-stock |
| 25mg | $1350 | In-stock |
| 50mg | $1760 | In-stock |
| 100mg | $2290 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-123481 |
| M.Wt: | 446.63 |
| Formula: | C28H38N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively[1]. In Vivo: When dosed in rats, JNJ-42253432 occupied the brain P2X7 channel with an ED50 of 0.3 mg/kg, corresponding to a mean plasma concentration of 42 ng/ml. JNJ-42253432 also increased serotonin levels in the rat brain, which is due to antagonism of the serotonin transporter (SERT) resulting in an ED50 of 10 mg/kg for SERT occupancy[1].
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