DPN
CAS No. : 1428-67-7
(Synonyms: Diarylpropionitrile)
| Size | Price | Stock |
|---|---|---|
| 5mg | $42 | In-stock |
| 10mg | $66 | In-stock |
| 25mg | $146 | In-stock |
| 50mg | $264 | In-stock |
| 100mg | $473 | In-stock |
| 250mg | $878 | In-stock |
| 500mg | $1430 | In-stock |
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| Cat. No. : | HY-12452 |
| M.Wt: | 239.27 |
| Formula: | C15H13NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases[1][2].
In Vitro:DPN has a 70-fold ERα relative binding affinity selectivity, and it is a full ERα agonist with a 78-fold ERα potency selectivity (EC50=0.85 nM for ERβ; EC50=66 nM for ERα)[1].
DPN (10 nM) prevents morphological alterations from Aβ1-42 (10 μM)-induced toxicity in cultured cortical neurons[2].
DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner[2].
DPN (0.1-100 nM) significantly reduces Aβ1-42-stimulated expression of Bax in a non-dose dependent manner[2].
DPN (0.1-100 nM) reduces activated IL-1 levels induced by Aβ1-42 treatment on cultured cortical neurons[2].
DPN (0.1-100 nM) suppresses the Aβ1-42-upregulated phosphorylation of JNK and p38[2].
In Vivo:DPN (10 μg; s.c.; daily; for 11 days) increases swimming and decreases immobility in the FST, and increases TPH protein expression in the dorsal raphe nucleus (DR) in rat model[3].
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