Conophylline
CAS No. : 142741-24-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $650 | In-stock |
| 5mg | $2050 | Get quote |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-N3619 |
| M.Wt: | 794.89 |
| Formula: | C44H50N4O10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis[1][2].
In Vitro:Conophylline (100 ng/ml; 48 hours) reproduces differentiationinducing activity but not apoptosis-inducing activity of activin[1].
Conophylline (100 ng/ml; 72 hours) exhibits the differentiation-inducing activity in AR42J cells and converts these cells to endocrine cells[1].
Conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase to induce differentiation of AR42J cells[1].
Conophylline reduces the expression of α-SMA and collagen-1 in rat HSC and Lx-2 cells[2].
Conophylline inhibits DNA synthesis induced by serum[2].
Conophylline also promots activation of caspase-3 and induces apoptosis in Lx-2 Cells[2].
In Vivo:Conophylline (0.9 mg/kg; p.o.; daily; for 12 weeks) attenuates formation of the liver fibrosis induced by TAA in vivo[2].
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