GSK805
CAS No. : 1426802-50-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $730 | In-stock |
| 100mg | $1090 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12776 |
| M.Wt: | 532.36 |
| Formula: | C23H18Cl2F3NO4S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity[1]. IC50 & Target:IC50: 8.4 (RORγt)[1] In Vitro:GSK805 (0.5 μM; 4 d) inhibits Th17 cell responses[2]. In Vivo:GSK805 (10 mg/kg; p.o. once per day for 35 days) improves the situation of mice with experimental autoimmune encephalomyelitis (EAE)[2]. GSK805 (30 mg/kg) inhibits Th17 cell responses in EAE mice[2].
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