Azt-pmap

Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity^[1]. AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection^[2]. Azt-pmap is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. In Vitro: Azt-pmap shows anti-HIV-1 activities in infected C8166 and JM cells with EC₅₀s of 0.08 and0.32 μM, respectively. Azt-pmap displays toxicities in infected C8166 and JM cells with TC₅₀s of 500 μM, respectively. Azt-pmap inhibits virus replication^[1].