CYD-2-11
CAS No. : 1425944-22-4
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| Cat. No. : | HY-120275 |
| M.Wt: | 358.39 |
| Formula: | C22H18N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CYD-2-11 is a selective Bax agonist with a Ki value of 34.1 nM. CYD-2-11 induces cell apoptosis and shows antiproliferative activity to breast cancer MDA-MB-231 and MCF-7 cell lines with IC50 values of 3.22 and 3.81 μM, respectively. CYD-2-11 suppresses tumor growth in MDA-MB-231 tumor models. CYD-2-11 can be used for the research of breast and lung cancer[1][2]. In Vitro:CYD-2-11 (0-100 μM; 48 h) shows anti-proliferation effects to breast cancer cells[1]. CYD-2-11 (5 μM; 48 h) selectively binds to Bax protein and induces apoptosis in NSCLC and SCLC cell lines[2]. In Vivo:CYD-2-11 (20 mg/kg; i.p.; once daily for 7 days) inhibits tumor growth[1]. CYD-2-11 (40 mg/kg; i.p.; once daily for 14 days) represses lung cancer growth and overcomes rapalog resistance with the combination of RAD001 (1 mg/kg) in murine lung cancer models[2].
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