Asperuloside
CAS No. : 14259-45-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $33 | In-stock |
| 5mg | $70 | In-stock |
| 10mg | $120 | In-stock |
| 20mg | $200 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N1382 |
| M.Wt: | 414.36 |
| Formula: | C18H22O11 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 25 mg/mL (ultrasonic) |
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways[1].
In Vitro:Asperuloside (0-160 μg/mL, 1 h) inhibits productions of NO, PGE2, TNF-α and IL-6 in LPS-Induced RAW 264.7 cells[1].
Asperuloside (0-5 mM, 24 h) inhibits cell viability and induces ER stress dependent apoptosis in leukemia cell lines (U937, HL-60, AML)[1].
In Vivo:Asperuloside (p.o., 3 mg/day, 0.3% in diet, daily, 12 weeks) reduces food intake, body weight, and adipose masses in rats consuming a high fat diet (HFD)[2].
Asperuloside (30 and 60 mg/kg, i.p., 30 days) inhibits tumor growth of U937 xenografts mice model[3].
Asperuloside (20-80 mg/kg, i.p.) relieves LPS-induced acute lung injury via inhibiting MAPK and NF-κB signaling in BALB/c mice[4].
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