L-690330
CAS No. : 142523-38-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $260 | In-stock |
| 25mg | $520 | In-stock |
| 50mg | $830 | In-stock |
| 100mg | $1350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101075 |
| M.Wt: | 298.12 |
| Formula: | C8H12O8P2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);H2O : 33.33 mg/mL (ultrasonic) |
L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase[1]. IC50 & Target: Ki: 0.27 μM (Recombinant human IMPase), 0.19 μM (Recombinant bovine IMPase), 0.30 μM (Human frontal cortex IMPase), 0.42 μM (Bovine frontal cortex IMPase)[1] In Vitro: L-690330 (50 μM; 1 hour) induces P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression in HEK293 cells[2]. In Vivo: L-690330 (intracerebroventricular injection; 0.1 μmol) has no effects on their motor activity and coordination in the beam walking, except a reduction in time spent in light in the dark/light test[3].
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