tans-4-Hydroxy-D-proline (hydrochloride)


CAS No. : 142347-81-7

142347-81-7
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Cat. No. : HY-W003511
M.Wt: 167.59
Formula: C5H10ClNO3
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 142347-81-7 :

tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

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