Tetrahydroaminopterin
CAS No. : 14231-41-5
(Synonyms: NSC 524120)
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| Cat. No. : | HY-117551 |
| M.Wt: | 444.44 |
| Formula: | C19H24N8O5 |
| Purity: | >98 % |
| Solubility: |
Tetrahydroaminopterin (NSC 524120) is a tetrahydropteridine analog and the tetrahydro-reduced derivative of aminopterin. Tetrahydroaminopterin is used for studies on phenylalanine hydroxylase cofactor binding and the structure-activity relationship of tetrahydrobiopterin analogs[1].
In Vitro:Tetrahydroaminopterin (NSC 524120) (up to 1 mM) shows no detectable inhibitory effect on partially purified rat liver phenylalanine hydroxylase in both spectrophotometric assays and tyrosine-forming activity assays[1].
Tetrahydroaminopterin (up to 1 mM; 10 min; 27°C) exhibits no intrinsic cofactor activity in the rat liver phenylalanine hydroxylase-catalyzed conversion of phenylalanine to tyrosine[1].
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