RTC-5
CAS No. : 1423077-49-9
(Synonyms: TRC-382)
| Size | Price | Stock |
|---|---|---|
| 5mg | $56 | In-stock |
| 10mg | $88 | In-stock |
| 25mg | $185 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $480 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-123952 |
| M.Wt: | 510.96 |
| Formula: | C24H22ClF3N2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 15 mg/mL (ultrasonic) |
RTC-5 (TRC-382) is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling[1]. IC50 & Target: IC50: EGFR[1] In Vitro: RTC-5 (0-40 μM; 48 hours) inhibits H1650 lung adenocarcinoma cell growth with an GI50 of 12.6μM[1]. RTC-5 (20-40 μM; 24 hours) negatively regulates PI3K-AKT and RAS-ERK pathways by decreasing phospho-AKT and phospho-ERK levels expression[1].
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