BRD9757


CAS No. : 1423058-85-8

1423058-85-8
Price and Availability of CAS No. : 1423058-85-8
Size Price Stock
5mg $100 In-stock
10mg $150 In-stock
25mg $290 In-stock
50mg $435 In-stock
100mg $652 In-stock
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Cat. No. : HY-117554
M.Wt: 127.14
Formula: C6H9NO2
Purity: >98 %
Solubility: H2O : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 1423058-85-8 :

BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs[1]. In Vitro:BRD9757 (compound 14) against HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, and HDAC9 with IC50 values of 0.638 μM, 1.79 μM, 0.694 μM, 21.80 μM, 18.32 μM, 12.61 μM, 1.09 μM, and >33.33 μM, respectively[1].
BRD9757 (compound 14; 10-30 μM; 24 h) selectively increases the level of Ac-tubulin, without increasing histone acetylation[1].

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