LY2922470
CAS No. : 1423018-12-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $450 | In-stock |
| 50mg | $1200 | In-stock |
| 100mg | $1900 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19835 |
| M.Wt: | 475.60 |
| Formula: | C28H29NO4S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
LY2922470 is a selective and orally active agonist for the G protein-coupled receptor 40 (GPR40). LY2922470 activates GPR40-mediated β-arrestin recruitment with EC50s of 7 nM (human GPR40), 1 nM (mouse GPR40) and 3 nM (rat GPR40). LY2922470 can be used for research of type 2 diabetes mellitus (T2DM)[1].
In Vitro:LY2922470 (20 μM, 24h) inhibits Palmitic acid (HY-N0830)-induced increase in ER stress markers and apoptosis markers, reduces Palmitic acid (HY-N0830)-induced nuclear condensation and fragmentation, and improves cell survival[2].
In Vivo:LY2922470 (5-30 mg/kg, po, single dose) reduce blood glucose levels, and increases the secretion of GLP-1 in mouse models[1].
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