TC-S 7009
CAS No. : 1422955-31-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-18371 |
| M.Wt: | 308.65 |
| Formula: | C12H6ClFN4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ? 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression[1][2].
IC50 & Target: Kd: 81 nM (HIF-2α)[1]
In Vitro: TC-S 7009 (0-100?μM; 72 hours; HPF cells) treatment shows greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions[2].
TC-S 7009 (50 μM) treatment almost completely inhibits the hypoxia-induced NFATc2 nuclear translocation[2].
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