1-Boc-azetidine-3-yl-methanol


CAS No. : 142253-56-3

142253-56-3
Price and Availability of CAS No. : 142253-56-3
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5g $14 In-stock
10g $18 In-stock
25g $41 In-stock
100g $150 In-stock
500g $749 In-stock
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Cat. No. : HY-40152
M.Wt: 187.24
Formula: C9H17NO3
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 142253-56-3 :

1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

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