Prothionamide
CAS No. : 14222-60-7
(Synonyms: Protionamide)
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| 500mg | $119 | In-stock |
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| Cat. No. : | HY-B0306 |
| M.Wt: | 180.28 |
| Formula: | C9H12N2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a Km value of 805.8 μM. Prothionamide reacts with NAD to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy[1][2][3][4][5].
IC50 & Target:Km: 805.8 μM (OCT1)
In Vitro:Prothionamide reacts with nicotinamide adenine dinucleotide (NAD) to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA[1].
Prothionamide is a substrate of OCT1 with a Km value of 805.8 μM[3].
In Vivo:Prothionamide (25 mg/kg; p.o.; 6 days a week; 12 weeks-13 months) shows good efficacy and prevents the selection of Isoniazid-resistant mutants when combined with Isoniazid (HY-B0329) in mouse tuberculosis model[4].
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