M2WJ332

M2WJ332 is an inhibitor of the M2 proton channel of the influenza A virus M2^S31N mutant M2. M2WJ332 potently inhibits the influenza A virus A/M2-S31N proton channel in Xenopus laevis oocytes, with an IC₅₀ of 16 μM. M2WJ332 completely inhibits plaque formation by the influenza A virus carrying the M2^S31N mutant. M2WJ332 is applicable to research related to influenza A virus infection^[1][2]. In Vitro:M2WJ332 (Compound 11) (100 μM; 2 min) potently inhibits the activity of the AM2-S31N proton channel in Xenopus laevis oocytes, while exerts extremely weak inhibitory effect on the activity of AM2-WT^[1].
M2WJ332 potently inhibits the replication of AM2-S31N-containing influenza A virus A/California/07/2009 (H1N1) in MDCK cells expressing ST6Gal I, with an EC₅₀ of 0.3 μM^[1].
M2WJ332 (48 h) exhibits cytotoxicity against MDCK cells with a CC₅₀ of 100 μM, and shows a CC₅₀ of 177.5 μM against A549 cells^[1].
M2WJ332 potently inhibits the replication of amantadine (HY-B0402)-resistant influenza A virus strain A/WSN/33 in MDCK cells, with an EC₅₀ of 153 nM, and completely suppresses plaque formation at 10 μM^[2].