AZD3839 (fumarate)
CAS No. : 1421852-78-9
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| Cat. No. : | HY-13438A |
| M.Wt: | 547.48 |
| Formula: | C28H20F3N5O4 |
| Purity: | >98 % |
| Solubility: |
AZD3839 fumarate is an orally available, selective, reversible inhibitor of the β-site amyloid precursor protein cleaving enzyme BACE1 that can cross the blood-brain barrier. AZD3839 fumarate inhibits recombinant human BACE1 with a Ki=26.1 nM. AZD3839 fumarate inhibits A40 production in SH-SY5Y cells with an IC50 of 4.8 nM. AZD3839 fumarate binds to BACE1 and reduces the Aβ amyloid produced by the cleavage of amyloid precursor protein (APP) by BACE1 and γ-secretase. AZD3839 fumarate can be used in the field of Alzheimer's disease research[1][2][3]. IC50 & Target:Ki = 26.1 nM (human BACE1)[1][2][3]
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