TMP920
CAS No. : 1421837-45-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $390 | In-stock |
| 100mg | $600 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117819 |
| M.Wt: | 454.56 |
| Formula: | C29H30N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM[1].
IC50 & Target: IC50: 0.03 μM (RORγt)[1]
In Vitro: TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Naïve CD4+ T cells[1].
TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro[1].
TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro[1].
TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets[1].
TMP920 significantly reduces RORγt-DNA interactions[1].
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