GN44028
CAS No. : 1421448-26-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $66 | In-stock |
| 5mg | $140 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $460 | In-stock |
| 50mg | $736 | In-stock |
| 100mg | $1140 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-110266 |
| M.Wt: | 305.33 |
| Formula: | C18H15N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
GN44028 is a potent and orally active hypoxia inducible factor (HIF)-1α inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. GN44028 can be used in the research of cancers[1][3].
IC50 & Target: IC50: 14 nM (HIF-1α)[1].
In Vitro: GN44028 (compound 2I, 0-30 µM approximately) has anti-proliferative activities against HCT116, HepG2 and HeLa cells[1].
GN44028 (0.001-1 μM, 4 h) inhibits the hypoxia-induced VEGF mRNA expression in HeLa cells[1].
GN44028 (20 nM, 10 days) abrogates the TGF‐β‐induced colony formation in HCT116 cells[2].
In Vivo: GN44028 (10 mg/kg, oral gavage) extends the survival rate of animals in mice bearing a mixed orthotopic tumor with PN12 and ME23 cells[3].
GN44028 (5 mg/kg, tail vein injection, twice a week) suppresses tumor growth in a subcutaneous colorectal cancer model[2].
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