Crenigacestat
CAS No. : 1421438-81-4
(Synonyms: LY3039478)
| Size | Price | Stock |
|---|---|---|
| 1mg | $71 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $1250 | In-stock |
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| Cat. No. : | HY-12449 |
| M.Wt: | 464.44 |
| Formula: | C22H23F3N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 34 mg/mL |
Crenigacestat (LY3039478) is an orally active Notch and γ-secretase inhibitor, with an IC50 of 1 nM in most of the tumor cell lines tested[1][2][3][4].
In Vitro: Crenigacestat (100 nM) exhibits anti-cancer activity in K07074 cells (a primary mouse liver tumor cell line)[2].
Crenigacestat (LY3039478) decreases expression of Myc and cyclin A1 (part of the NOTCH-driven proliferative signature) in murine and human model systems. Crenigacestat (LY3039478) treatment also leads to G0/G1 cell cycle arrest in CCRCC cells[3].
In Vivo: Crenigacestat (8 mg/kg, oral gavage three times a week) resulted in significantly increases survival and delayed tumor growth in independent cohorts of mice demonstrating in vivo efficacy in CCRCC[3].
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