Osimertinib (Standard)
CAS No. : 1421373-65-0
(Synonyms: AZD-9291 (Standard); Mereletinib (Standard))
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| Cat. No. : | HY-15772R |
| M.Wt: | 499.61 |
| Formula: | C28H33N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (125.10 mM; Need ultrasonic) |
Osimertinib (Standard) is the analytical standard of Osimertinib. This product is intended for research and analytical applications. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer[1]. IC50 & Target:IC50: 1 nM (EGFRL858R/T790M), 12 nM (EGFRL858R)[1]
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