Levoketoconazole
CAS No. : 142128-57-2
(Synonyms: (-)-Ketoconazole; (-)-Ketoconazol; (-)-R 41400)
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $290 | In-stock |
| 100mg | $470 | In-stock |
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| Cat. No. : | HY-B0105B |
| M.Wt: | 531.43 |
| Formula: | C26H28Cl2N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
Levoketoconazole ((-)-Ketoconazole) is the 2S,4R enantiomer derived from racemic Ketoconazole (HY-B0105). Levoketoconazole is a potent and orally active cortisol synthesis inhibitor. Levoketoconazole inhibits key steps in cortisol and testosterone synthesis by inhibiting CYP11B1, CYP11A1, and CYP17A1. Levoketoconazole can be used for research on endogenous Cushing’s syndrome[1][2].
In Vitro:Levoketoconazole (0.05-5 µM, 24-72 h) potently suppresses cortisol production in HAC15 cells with an IC50 of 0.300 µM (72 h)[3].
Levoketoconazole (0.1-10 µM, 1-7 days) inhibits cell number (7 days IC50 = 1.05 µM) in a time- and dose-dependent manner, and also significantly inhibits ACTH secretion in corticotroph pituitary murine AtT20 cells after 3 days of treatment[3].
Levoketoconazole (5 µM, 7 days) significantly inhibits cell number after 7 days in primary human corticotroph pituitary adenoma cultures[3].
In Vivo:Levoketoconazole inhibits serum corticosterone in rats[3].
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