NVP-TNKS656
CAS No. : 1419949-20-4
(Synonyms: TNKS656)
| Size | Price | Stock |
|---|---|---|
| 1mg | $100 | In-stock |
| 5mg | $360 | In-stock |
| 10mg | $540 | In-stock |
| 25mg | $1080 | In-stock |
| 50mg | $1620 | In-stock |
| 100mg | $2430 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13990 |
| M.Wt: | 494.58 |
| Formula: | C27H34N4O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 35 mg/mL (ultrasonic;warming;heat to 60°C) |
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, and is > 300 fold selectivity against PARP1 and PARP2. IC50 & Target: IC50: 6 nM (TNKS2)[1] In Vivo: NVP-TNKS656 (30 or 100 mg/kg, p.o.) exhibits good exposure and moderate oral bioavailability of 32% and 53%, respectively. Some slight overproportional increase in oral exposure is observed between 30 and 100 mg/kg with the dose normalized AUC for the 100 mg/kg dose being 2-fold higher than for the 30 mg/kg dose. Mice treated with NVP-TNKS656 (350 mg/kg, p.o.) show good plasma and tumor exposures corresponding to AUC0-24h of 515 and 325 μM·h, respectively[1].
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- Cat. No.:
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