A-81282
CAS No. : 141872-46-0
(Synonyms: Abbott 81282)
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| Cat. No. : | HY-101823A |
| M.Wt: | 429.47 |
| Formula: | C23H23N7O2 |
| Purity: | >98 % |
| Solubility: |
A-81282 (Abbott 81282) is an antagonist of angiotensin II's AT1 receptor, with a pA2 value of 9.64 at the AT1 receptor in rabbit aorta. A-81282 also demonstrates significant inhibitory action on the binding of [125i]_Sar1_lle8_Angiotensin_ll to rat liver membranes, with a pKI value of 8.505. A-81282 has antihypertensive activity and can effectively lower blood pressure in renal artery-ligated rats[1].
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