NMS-873
CAS No. : 1418013-75-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $78 | In-stock |
| 10mg | $147 | In-stock |
| 50mg | $506 | In-stock |
| 100mg | $782 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15713 |
| M.Wt: | 520.67 |
| Formula: | C27H28N4O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20.5 mg/mL (ultrasonic;warming) |
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM. IC50 & Target: IC50: 30 nM[1] In Vitro: NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC50 values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC50 values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC50 value[1].
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