HDAC8-IN-1
CAS No. : 1417997-93-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $40 | In-stock |
| 5mg | $85 | In-stock |
| 10mg | $136 | In-stock |
| 25mg | $272 | In-stock |
| 50mg | $408 | In-stock |
| 100mg | $612 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-111342 |
| M.Wt: | 345.39 |
| Formula: | C22H19NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.
IC50 & Target:IC50: 27.2 nM (HDAC8)
In Vitro:HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells[1].
HDAC8-IN-1 (200 nM, 1-3 days) slightly reverses the IL-4-induced Foxp3 repression as a class I HDAC inhibitor; while class II HDAC inhibitors dramatically recovers the Foxp3 expression, and promotes the differentation of regulatory T cell[2].
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