Carboxypyridostatin
CAS No. : 1417638-60-8
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| Cat. No. : | HY-112680 |
| M.Wt: | 706.71 |
| Formula: | C35H34N10O7 |
| Purity: | >98 % |
| Solubility: |
Carboxypyridostatin is a G-quadruplex ligand. Carboxypyridostatin has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxypyridostatin reduces cell proliferation and hinders stress granule (SG) formation[1][2][3].
In Vitro:Carboxypyridostatin (1-25 μM; 3 days) reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres, and blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures[1].
Carboxypyridostatin (10 μM; 24 h) hinders stress granule (SG) formation in U2OS cells[3].
In Vivo:Carboxypyridostatin (10 mg/kg; i.p.; every 12 h; 3 injections) significantly reduces the number of PCNA-expressing cells in the adult SVZ and increases the number of OLIG2-expressing cells in the corpus callosum in mice[1].
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