PCPA methyl ester (hydrochloride)
CAS No. : 14173-40-1
(Synonyms: 4-Chloro-DL-phenylalanine methyl ester (hydrochloride))
| Size | Price | Stock |
|---|---|---|
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| 5g | $88 | In-stock |
| 10g | $116 | In-stock |
| 25g | $289 | In-stock |
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| Cat. No. : | HY-101456 |
| M.Wt: | 250.13 |
| Formula: | C10H13Cl2NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability[1][2].
In Vivo: PCPA methyl ester hydrochloride (250-500 mg/kg; oral administration; daily; for 8 weeks) treatment significantly decreases serotonin levels in both hippocampus and cortex[3].
In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or ip PCPA methyl ester hydrochloride, respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% (oral) and 50% (ip)[3].
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