AMG 333
CAS No. : 1416799-28-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $85 | In-stock |
| 25mg | $176 | In-stock |
| 50mg | $300 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-112703 |
| M.Wt: | 453.32 |
| Formula: | C20H12F5N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC50 of 13 nM. IC50 & Target:IC50: 13 nM (TRPM8)[1] In Vivo:AMG 333 (0.6-3 mg/kg, p.o., single dose) dose-dependently inhibits wet-dog shake behavior in the Icilin (HY-11062)-induced wet-dog shake Sprague−Dawley rat model, demonstrating that AMG 333 effectively blocks the TRPM8 target[1]. AMG 333 (1-3 mg/kg, p.o., single dose) dose-dependently blocks blood pressure elevation in the cold stimulation-induced blood pressure elevation Sprague−Dawley rat model, indicating that AMG 333 effectively acts on the TRPM8 target[1].
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