RO-5963
CAS No. : 1416663-77-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $84 | In-stock |
| 5mg | $210 | In-stock |
| 10mg | $290 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $840 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-120086 |
| M.Wt: | 518.90 |
| Formula: | C24H21ClF2N4O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
RO-5963 is a dual p53-MDM2 and p53-MDMX inhibitor with IC50s of ~17 nM and ~24 nM, respectively[1].
IC50 & Target:IC50: ~17 nM (p53-MDM2), ~24 nM (p53-MDMX)[1]
In Vitro: RO-5963 (10-20 μM; 48 hours) shows much higher apoptotic activity than Nutlin in both MCF7 and ZR75-30 cell lines[1].
RO-5963 (10 μM, 24 hours) effectively activats p53 and elevates p21 and MDM2 levels[1].
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