GB-88
CAS No. : 1416435-96-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $450 | In-stock |
| 10mg | $750 | In-stock |
| 25mg | $1350 | In-stock |
| 50mg | $2250 | In-stock |
| 100mg | $3350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-120261 |
| M.Wt: | 546.70 |
| Formula: | C32H42N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 31.25 mg/mL (ultrasonic) |
GB-88 is an oral, selective non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 µM[1].
IC50 & Target:PAR2[1]
In Vitro: GB-88 inhibits iCa2+ release induced in HT29 cells by trypsin, 2f-LIGRLO-NH2 and GB110 (PAR2 agonists). And antagonism by GB-88 is agonist dependent[1].
In Vivo: GB-88 (10 mg/kg, p.o. in olive oil) is both orally active and anti-inflammatory in vivo, with specific antagonist activity against four structurally and mechanistically different PAR2 agonists (2f-LIGRLO-NH2, trypsin, SLIGRL-NH2 and GB110)[1].
GB-88 inhibits PAR2-induced acute inflammation in vivo[1].
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- GB-88
- Cat. No.:
- HY-120261
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