GSK-A1
CAS No. : 1416334-69-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $65 | In-stock |
| 5mg | $125 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $900 | In-stock |
| 100mg | $1620 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-125118 |
| M.Wt: | 574.63 |
| Formula: | C29H27FN6O4S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 2 mg/mL;H2O : < 0.1 mg/mL (ultrasonic) |
GSK-A1 is a selective type III phosphatidylinositol 4-kinase PI4KA (PI4KIIIα) inhibitor with a pIC50 of 8.5-9.8. GSK-A1 inhibits PtdIns(4,5)P2 resynthesis with an IC50 of about 3 nM. GSK-A1 potently decreases the levels of PtdIns(4)P with a negligible effect on PtdIns(4,5)P2. GSK-A1 has the potential for anti-hepatitis C virus (HCV) research[1].
In Vitro:GSK-A1 (100 nM, 30 min) reduces HSPA1A localization at the plasma membrane in HeLa cells[2].
GSK-A1 (0-8 μM, 48 h) enhances Doxorubicin (HY-15142A) efficacy in resistant leukemia cells (K562/Adr and HL-60/Adr cells)[3].
GSK-A1 (0-50 nM) stimulates phosphorylation of LATS and YAP in HEK293A cells[4].
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