GSK2795039
CAS No. : 1415925-18-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $115 | In-stock |
| 10mg | $174 | In-stock |
| 25mg | $340 | In-stock |
| 50mg | $510 | In-stock |
| 100mg | $765 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-18950 |
| M.Wt: | 450.56 |
| Formula: | C23H26N6O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption[1]. GSK2795039 reduces apoptosis[2]. In Vitro: GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells[2]. In Vivo: GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) decreases activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein[1].
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