TC-G 1005
CAS No. : 1415407-60-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $420 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $1300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-110173 |
| M.Wt: | 399.48 |
| Formula: | C25H25N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
TC-G 1005 is a potent, selective and orally active agonist of the BA receptor Takeda G protein-coupled receptor 5 (TGR5), with EC50s of 0.72 and 6.2 nM for hTGR5 and mTGR5, respectively. TC-G 1005 can reduce glucose levels in vivo[1][2].
IC50 & Target: IC50: 0.72 nM (hTGR5); 6.2 nM (mTGR5)[1]
In Vitro: TC-G 1005 activates human and mouse TGR5 with EC50s of 0.72 nM and 6.2 nM, respectively[1].
In Vivo: TC-G 1005 (25-100 mg/kg; a single p.o.) stimulates GLP-1 secretion in imprinting control region (ICR) mice[1].
TC-G 1005 (50 mg/kg; a single p.o.) causes a 49% reduction in blood glucose AUC0-120 min in ICR mice[1].
TC-G 1005 (50 mg/kg; a single p.o.) significantly reduces blood glucose at 4, 6, 10, and 24 h in db/db mice[1].
TC-G 1005 (5 mg/kg; p.o.) exhibits rather low plasma exposure, with a Cmax of 56 ng/mL and a t1/2 of 1.5 in rats[1].
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- TC-G 1005
- Cat. No.:
- HY-110173
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