MI-192
CAS No. : 1415340-63-4
| Size | Price | Stock |
|---|---|---|
| 500μg | $85 | Get quote |
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| Cat. No. : | HY-110264 |
| M.Wt: | 383.44 |
| Formula: | C24H21N3O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities[1][2]. In Vitro: MI-192 (0.15-1 μM; 72 h) induces differentiation and is cytotoxic through promotion of apoptosis in acute myeloid leukaemic cell lines U937, HL60 and Kasumi-1[1]. In Vivo: MI-192 (40 mg/kg; i.p; once a day; for 3 days) shows the neuroprotective activity in the mouse brain subjected to photothrombotic stroke[2].
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