Trifloxystrobin

Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases^{[1][2][3][4][5]}. IC50 & Target:EC50: 23.0 μg/L (Daphnia magna neonate), 1.7 μg/L (Daphnia magna embryos)^[1] In Vitro:Trifloxystrobin (2-500 μM, 24-48 h) reduces the viability of HaCaT cells^[1].
Trifloxystrobin (0.5 μM, 48 h) induces apoptosis via the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated pathway in HaCaT cells^[1].
Trifloxystrobin (25-200 μM, 4-48 h) have neurotoxicity in differentiated human SH-SY5Y cells^[2]. In Vivo:Trifloxystrobin (30.0-58.6 μg/L, zebrafish embryos were exposed to trifloxystrobin for 96 h post-fertilization (hpf)) is highly toxic to zebrafish embryos^[3].
Trifloxystrobin (Soils were prepared by spiking 50 g of soil with 1mL of trifloxystrobin-acetonitrile solution. Following mixing and acetonitrile volatilization, spiked soil was mixed with additional soil to prepare 500 g aliquots containing 0.1, 1.0 and 2.5 mg/kg trifloxystrobin for 7-56 days) induces oxidative stress and DNA damage in two soils^[4].