IRE1α kinase-IN-2
CAS No. : 1414938-21-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $208 | In-stock |
| 10mg | $347 | In-stock |
| 25mg | $694 | In-stock |
| 50mg | $1111 | In-stock |
| 100mg | $1777 | In-stock |
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| Cat. No. : | HY-18509 |
| M.Wt: | 504.51 |
| Formula: | C27H23F3N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines[1]. In Vitro: IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even during ER stress[1].
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