Fuzapladib
CAS No. : 141283-87-6
(Synonyms: IS-741)
| Size | Price | Stock |
|---|---|---|
| 5mg | $220 | In-stock |
| 10mg | $330 | In-stock |
| 25mg | $620 | In-stock |
| 50mg | $830 | In-stock |
| 100mg | $1100 | In-stock |
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| Cat. No. : | HY-19151 |
| M.Wt: | 379.40 |
| Formula: | C15H20F3N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Fuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site[1][2]. In Vitro:Fuzapladib (IS-741) (1 μM, 3 h) can significantly inhibit the adhesion of HL-60 cells to HUVEC under the stimulation of lipopolysaccharide[3]. In Vivo:Fuzapladib (IS-741) (p.o., 50 mg/kg, 7 days) inhibits neutrophil infiltration into inflamed lesions, and is effective for attenuating rat trinitrobenzene sulfonic acid (TNBS) ileitis[4].
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