Tr-PEG5-OH
CAS No. : 141282-24-8
| Size | Price | Stock |
|---|---|---|
| 1g | $220 | Get quote |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-120845 |
| M.Wt: | 480.59 |
| Formula: | C29H36O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tr-PEG5-OH is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
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