JNK-IN-8 (GMP)
CAS No. : 1410880-22-6
(Synonyms: JNK Inhibitor XVI (GMP))
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| Cat. No. : | HY-13319G |
| M.Wt: | 507.59 |
| Formula: | C29H29N7O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
JNK-IN-8 (JNK Inhibitor XVI) (GMP) is JNK-IN-8 (HY-13319) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. JNK-IN-8 is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1].
IC50 & Target:IC50: 4.7/18.7/1 nM (JNK1/2/3)[1]
In Vitro:JNK-IN-8 (GMP) (10 μM) reduces WNT3A-mediated neuronal differentiation[1].
JNK-IN-8 (GMP) (2 μM, 7 days) enhances the self-renewal of human hematopoietic stem cells (HSCs) through the downregulation of C-JUN phosphorylation[1].
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