Neryl acetate

Neryl acetate is an essential oil component. Neryl acetate upregulates genes associated with epidermal differentiation, skin barrier formation and ceramide synthesis; it also increases filaggrin expression, total lipid and ceramide contents. Neryl acetate acts as the core driver mediating the skin barrier-forming and antibacterial effects of Helichrysum italicum essential oil^[1][2]. In Vitro:Neryl acetate (0.03%; 5 days) significantly increases the protein level of filaggrin by 51% in full-thickness human abdominal skin explants treated for 5 days, thereby promoting the formation of the cornified envelope^[1].
Neryl acetate (0.03%; 5 days) increases the production of neutral lipids in the intercellular spaces of epidermal cells in full-thickness human abdominal skin explants after 5 days of treatment^[1].
Neryl acetate (0.03%; 5 days) significantly increases the total epidermal ceramide level by 64.2% in 5-day treated human full-thickness abdominal skin explants, and specifically elevates the levels of multiple ceramide subclasses^[1].
H. italicum essential oil with high neryl acetate content exhibits significant bacteriostatic/bactericidal activity against Gram-positive bacteria and Candida albicans (with an MIC as low as < 1.4 μg/mL against S. aureus), and inhibits S. aureus biofilm formation. Its antimicrobial efficacy results from the synergistic effect of neryl acetate with components such as α-pinene (HY-N1367) and γ-curcumene. It shows weak activity against Gram-negative bacteria, and its overall antimicrobial spectrum is closely related to the chemotype of the essential oil^[2].