PF-06465469
CAS No. : 1407966-77-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $485 | In-stock |
| 50mg | $825 | In-stock |
| 100mg | $1350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108691 |
| M.Wt: | 523.63 |
| Formula: | C30H33N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 11 mg/mL (ultrasonic) |
PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM. PF-06465469 also inhibits BTK. PF-06465469 inhibits cell migration in response to CXCL12. PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma[1][2].
IC50 & Target:IC50: 2 nM (ITK)[1]
In Vitro: PF-06465469 (2 µM, 24 h) reduces ITK phosphorylation in Jurkat cells and inhibits migration of Jurkat cells in response to CXCL12[1].
PF-06465469 (1 µM) significantly decreases CD69, PD-1 and LAG-3 expression in CAR-T cells cocultured with MEC1 cells[2].
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